Bota Biosciences and Syensqo Expand Re2 Coffea Arabica Peptide to Global Personal Care Market

AI-Driven Biotechnology Upcycled Coffee Grounds into High-Performance Hair Care and Scalp Care Bioactive

In March 2026, Bota Biosciences (referred to as Bota) officially initiated a collaboration with Syensqo to expand the international market for Re2 Coffea Arabica Peptide. This bioactive ingredient will be distributed through Syensqo’s commercial network, accelerating its global reach. The launch signifies that the strategic partnership between Bota and Syensqo has entered a substantive phase of global delivery, highlighting their strong synergy in driving sustainable innovation.

The launch highlights Bota position as a global leader in Physical AI-driven biofoundry platform, integrating end-to-end capabilities in AI, synthetic biology, and industrial-scale biomanufacturing. It also marks a deeper phase of the collaboration between two companies in advancing sustainable innovation in hair care and scalp care since the establishment of the strategic partnership announced in 2025.

From Coffee Grounds to Precision Bioactives: AI-Powered Discovery & Biotechnology

Re2 Coffea Arabica Peptide exemplifies circular innovation. Sourced from discarded coffee grounds collected from eco-plantations in Pu’er, Yunnan, this by-product is upcycled into a high-performance bioactive ingredient, transforming waste into value for advanced hair care and scalp care applications.

Unlike traditional screening, Bota leverages its self-developed Physical AI platform to perform deep intelligent modeling and multi-scale screening of natural proteins extracted from coffee grounds:

• Intelligent Sequence Identification: By analyzing vast biological datasets, the platform precisely identifies peptide sequences with the highest potential for soothing the scalp and strengthening hair fibers.
• Directed Enzymatic Evolution: Through AI-driven enzyme selection and experimental validation, these targeted sequences are converted into high-value bioactive ingredients, enabling end-to-end transformation from “discovery” to “production”.

Advanced Multi-Dimensional Repair Performance

Re2 Coffea Arabica Peptide has demonstrated strong clinical efficacy in scalp and hair repair. It reinforces the scalp barrier by increasing moisture and improving softness, while helping to soothe irritation and visibly reduce redness. The ingredient also enhances hair manageability and texture by smoothing damaged and frizzy hair, reducing combing resistance, and delivering silky smoothness from root to tip.

Industrial-Scale Delivery from Concept to Mass Production

The launch of this ingredient demonstrates Bota’s ability to translate cutting-edge biotechnology into scalable industrial solutions. By combining advanced AI discovery with efficient biomanufacturing processes, the company delivers ingredients that balance high performance with cost-efficient and sustainable production, providing partners with reliable and scalable supply solutions.

“The collaboration with Syensqo fully demonstrates the value of Bota’s Physical-AI driven biofoundry platform, enabling us to translate discovery into scalable industrial delivery, supported by Syensqo’s deep market expertise and global commercial footprint ” said Dr. Zhu Jie, Vice President of Bota. “We repurpose coffee grounds into high-value ingredients through AI screening and biomanufacturing, we are taking a tangible step towards our mission of scaling nature’s possibilities through the convergence of AI and biology to power a sustainable future.”

As we look to the future, we will continue to deepen our collaboration in hair care and scalp care, bringing more AI-driven innovations to market and unlocking new possibilities for the future of sustainable beauty.

About Bota Biosciences

Bota Biosciences is a global leader in Physical AI-driven biomanufacturing, dedicated to making biotechnology a reliable and scalable engine of productivity. By integrating end-to-end capabilities in AI, synthetic biology, and industrialization, Bota pioneers a new paradigm in biomanufacturing research and production. Our world-leading Physical-AI driven biofoundry platform spans strain engineering, process development, and scale-up production—translating complex biology into scalable solutions for diverse industries, from food and nutrition to personal care and beyond. Bota partners with global customers to deliver greener, more efficient bio-solutions, accelerating industry-wide adoption and the transition to a sustainable future.

For more information, visit www.bota.bio.

About Syensqo

Syensqo is a science company developing groundbreaking solutions that enhance the way we live, work, travel and play. Inspired by the scientific councils which Ernest Solvay initiated in 1911, we bring great minds together to push the limits of science and innovation for the benefit of our customers, with a diverse, global team of more than 13,000 associates in 30 countries.

Our solutions contribute to safer, cleaner, and more sustainable products found in homes, food and consumer goods, planes, cars, batteries, smart devices and health care applications. Our innovation power enables us to deliver on the ambition of a circular economy and explore breakthrough technologies that advance humanity.

For more information, visit www.syensqo.com.